Key result
Cryo-electron microscopy of Drosophila flight muscle thick filaments at 7 Å resolution revealed that myosin tails are arranged in curved molecular crystalline layers with disordered myosin heads.
Population
Thick filaments of flight muscle of the fruit fly Drosophila melanogaster
Design
CryoEM structural study at 7 Å resolution
Authors
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Drosophila filament model extends myosin assembly insights; leaves open validation in mammalian cardiac sarcomeres.
The cryoEM structure of Drosophila flight muscle thick filaments reveals striking evolutionary conservation of myosin tail arrangement despite disordered myosin heads.
Daneshparvar et al. (2020) studied this question. Cryo-electron microscopy was evaluated. Cryo-electron microscopy of Drosophila flight muscle thick filaments at 7 Å resolution revealed that myosin tails are arranged in curved molecular crystalline layers with disordered myosin heads.
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