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We describe the design of the first non-pharmacological prevention trials of Parkinson’s Disease worldwide: the randomised controlled ‘Slow-SPEED’ trials. The three trials examine the feasibility and preliminary efficacy of a gamified, remotely administered exercise intervention vs. active control program over 18-36 months in the Netherlands (n=110), United Kingdom (n=110) and United States (n=600). Each trial focuses on a complementary prodromal subgroup: isolated/idiopathic REM sleep behavioural disorder, hyposmia, or LRRK2 / GBA1 mutation carriers. These trials will provide unique insights for large-scale Parkinson’s Disease prevention studies.
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Oosterhof et al. (2026) studied this question.