What question did this study set out to answer?

July 1, 1997Clinical Science

Repeatability of Spectral Components of Short-Term Blood Pressure and Heart Rate Variability during Acute Sympathetic Activation in Healthy Young Male Subjects

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Why the study?

Are changes in the spectral components of short-term blood pressure and heart rate variability repeatable during acute sympathetic activation in healthy young male subjects?

Key Points

To evaluate the intra-observer repeatability of spectral components of short-term blood pressure and heart rate variability during acute reflex sympathetic activation.
Assessed intra-observer repeatability in healthy young male volunteers during sympathetic activation induced by nitroglycerin infusion (n = 10, repeated 2 days apart) or 60-degree head-up tilt (n = 13, repeated 1 week apart).
Quantified low-frequency (LF) components in absolute and normalized units along with the LF/high-frequency (HF) ratio, estimating repeatability using Bland and Altman analysis.
Bland and Altman plots demonstrated that changes in LF components and the LF/HF ratio were sufficiently repeatable for application over intervals of up to 1 week.
Sample-size projections indicated that reporting spectral components in normalized units and using a cross-over design minimized the necessary sample size for clinical studies targeting LF changes.

Structured PICO

Are changes in the spectral components of short-term blood pressure and heart rate variability repeatable during acute sympathetic activation in healthy young male subjects?

Population

23 healthy young male volunteers (n=10 for nitroglycerin infusion, n=13 for 60 degrees head-up tilt)

Intervention

Acute sympathetic activation induced by nitroglycerin infusion or 60 degrees head-up tilt, repeated on two occasions (2 days and 1 week apart respectively)

Outcome

Intra-observer repeatability of changes in the low-frequency (LF) components of cardiovascular variability and in the LF/HF ratiosurrogate

Spectral components of short-term blood pressure and heart rate variability are sufficiently repeatable over a 1-week period for use in clinical studies assessing sympathetic activity.

Discussion

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Implication

May support LF and LF/HF use in 1-week sympathetic studies in healthy males; leaves open validation in patients.

Cite This Study

Cloarec-Blanchard et al. (1997) studied this question.

synapsesocial.com/papers/6a7fa2ab125bc40038b8e5b6 https://doi.org/10.1042/cs0930021

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Repeatability of Spectral Components of Short-Term Blood Pressure and Heart Rate Variability during Acute Sympathetic Activation in Healthy Young Male Subjects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Repeatability of Spectral Components of Short-Term Blood Pressure and Heart Rate Variability during Acute Sympathetic Activation in Healthy Young Male Subjects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider