Why the study?
No animal model completely recapitulates human HFrEF, making it critical to evaluate the strengths and weaknesses of each model to guide selection in basic and translational research.
This review provides a comprehensive overview of animal models for HFrEF, emphasizing the need to carefully select models based on the specific scientific question since no single model perfectly mimics human disease.
No takes yet. Share an insight, caveat, or question.
Should not alter current HFrEF management; leaves open which models will best translate mechanistic insights to patients.
Pilz et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: