Why the study?
Renin-mediated cleavage of angiotensin I from angiotensinogen is the rate-limiting step of the renin-angiotensin cascade, but its detailed molecular mechanism is unclear.
Population
Glycosylated human AGT and renin
Design
Structural, mutagenesis, and kinetic analysis
Authors
Loading...
May guide allosteric AGT inhibitor design; leaves open in vivo efficacy for hypertension.
Elucidation of the structural basis for renin-mediated angiotensinogen cleavage provides insights for developing novel antihypertensive agents targeting AGT.
Yan et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: