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October 1, 1999British Journal of PharmacologyOpen Access

Differential effects of bepridil on functional properties of troponin C in slow and fast skeletal muscles

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Authors

PKPhilippe KischelUniversité de Picardie Jules Verne LSL. StevensLa Trobe University YMYvonne MounierInstitut de Biologie de Lille

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Implication

Bepridil leaves maximal Ca2+-activated tension unchanged in skinned fibres; leaves open TnC Ca2+-sensitizing effects for further study.

Key Points

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Cite This Study

Kischel et al. (1999) studied this question.

synapsesocial.com/papers/6a7fd4f3b6064379b3639eb0 https://doi.org/10.1038/sj.bjp.0702820

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Binding of a calcium sensitizer, bepridil, to cardiac troponin C. A fluorescence stopped-flow kinetic, circular dichroism, and proton nuclear magnetic resonance study.1990 · 43 citations
2Calcium Binding and Tension Development in Detergent-Treated Muscle Fibers1974 · 86 citations
3Altered Ca2+ dependence of tension development in skinned skeletal muscle fibers following modification of troponin by partial substitution with cardiac troponin C.1986 · 100 citations
4The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase.1975 · 920 citations
5Calcium-Induced Structural Transition in the Regulatory Domain of Human Cardiac Troponin C<sup>,</sup>1997 · 187 citations