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August 15, 1994Annals of Internal Medicine

Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis

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Authors

AJAnthony G. JohnsonTranslational Research Institute

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Implication

Meta-analysis of randomized trials reveals nonsteroidal anti-inflammatory drugs elevate blood pressure and counteract antihypertensives, indicating potential risks for hypertension-related morbidity.

Key Points

  • To evaluate the quantitative impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on blood pressure and related renal and hemodynamic markers.
  • Searched eight databases to identify 38 randomized, placebo-controlled trials and 12 randomized, active-comparator trials evaluating NSAIDs.
  • Calculated pooled mean treatment effects across trials for blood pressure, weight, creatinine clearance, plasma renin activity, and urinary excretion of sodium and prostaglandins.
  • NSAIDs significantly elevated supine mean blood pressure by 5.0 mm Hg (95% CI, 1.2 to 8.7 mm Hg) without significantly altering other measured renal or biochemical variables.
  • NSAIDs antagonized the antihypertensive effect of beta-blockers (blood pressure elevation, 6.2 mm Hg; 95% CI, 1.1 to 11.4 mm Hg) more markedly than vasodilators or diuretics.
  • Piroxicam caused the greatest increase in blood pressure (6.2 mm Hg; 95% CI, 0.8 to 11.5 mm Hg), whereas sulindac and aspirin demonstrated the least hypertensive effect.

Cite This Study

Anthony G. Johnson (1994) studied this question.

synapsesocial.com/papers/6a7fd8d7f781fc9f820fe66ahttps://doi.org/10.7326/0003-4819-121-4-199408150-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension2012 · 89 citations
  2. 2Do Non-Steroidal Antiinflammatory Drugs Influence the Effects of Antihypertensive Drugs?1986 · 3 citations
  3. 3An Analytical Study of NSAIDs Affecting Heart Functions2022
  4. 4The Effects of Nonsteroidal Anti-inflammatory Drugs on Blood Pressures of Patients With Hypertension Controlled by Verapamil1995 · 78 citations
  5. 5Impact of NSAIDs on cardiovascular risk and hypertension2011 · 2 citations