January 1, 2018Case Reports in RheumatologyOpen Access

Hemorrhagic Tamponade as Initial Manifestation of Systemic Lupus with Subsequent Refractory and Progressive Lupus Myocarditis Resulting in Cardiomyopathy and Mitral Regurgitation

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Structured PICO

Population

1 young woman with Systemic Lupus Erythematosus (SLE) presenting with pericarditis and hemorrhagic tamponade, progressing to severe cardiomyopathy (ejection fraction 25%) and severe (+4) mitral regurgitation.

Intervention

Cyclophosphamide (administered after failure of hydroxychloroquine, high-dose steroids, intravenous immunoglobulins, azathioprine, and mycophenolate mofetil).

Outcome

Improvement in ejection fraction and mitral regurgitation severitysurrogate

Cyclophosphamide may be an effective rescue therapy for refractory lupus myocarditis presenting with severe cardiomyopathy and mitral regurgitation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for cyclophosphamide in refractory lupus myocarditis; prospective trials needed before clinical adoption.

Cite This Study

Marijanovich et al. (2018) studied this question.

synapsesocial.com/papers/6a7feae833a54265d53d2db9 https://doi.org/10.1155/2018/7635982

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Hemorrhagic Tamponade as Initial Manifestation of Systemic Lupus with Subsequent Refractory and Progressive Lupus Myocarditis Resulting in Cardiomyopathy and Mitral Regurgitation

Structured PICO

Discussion

Implication

Cite This Study

Hemorrhagic Tamponade as Initial Manifestation of Systemic Lupus with Subsequent Refractory and Progressive Lupus Myocarditis Resulting in Cardiomyopathy and Mitral Regurgitation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider