Why the study?
Are elevated levels of endothelial derived haemostatic variables associated with increased mortality in patients on long-term oral anticoagulant treatment?
Population
n=212 out-patients treated with oral anticoagulants with high morbidity due to thromboembolic disease
Comparison
Elevated levels of endothelial derived… vs Lower levels of endothelial derived haemostatic…
Design
Cohort
Follow-up
3.8 years
Authors
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vWF may refine mortality risk stratification in anticoagulated patients; hypothesis-generating and requires prospective validation before clinical use.
Are elevated levels of endothelial derived haemostatic variables associated with increased mortality in patients on long-term oral anticoagulant treatment?
Elevated levels of endothelial-derived haemostatic factors, specifically vWF and tPA, serve as independent predictors of all-cause and vascular mortality in patients receiving long-term oral anticoagulation.
Brännström et al. (1995) studied this question.
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