What question did this study set out to answer?

To determine whether hyperinsulinaemia and related metabolic disturbances persist in patients with well-controlled hypertension compared to normotensive controls.

October 1, 1990Journal of Hypertension

Hyperinsulinaemia and other metabolic disturbances in well-controlled hypertensive men and women: an epidemiological study of the Dalby population

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Why the study?

Do well-controlled hypertensive subjects have higher insulin and C-peptide levels compared to normotensive controls?

Population

598 subjects from the Dalby population, comprising 310 subjects with well-controlled hypertension for >5…

Comparison

Diagnosis of treated hypertension vs Normotensive controls

Design

Cross-sectional

Authors

PNPeter NilssonScience for Life Laboratory LLLars LindholmPreventive Cardiology BNBengt Scherst nLund University

Discussion

Member takes

Implication

Persistent hyperinsulinemia despite BP control should not alter targets; leaves open causal links to outcomes in longitudinal studies.

Key Points

To determine whether hyperinsulinaemia and related metabolic disturbances persist in patients with well-controlled hypertension compared to normotensive controls.
Conducted an epidemiological matched case-control study comparing 310 patients with hypertension for >5 years (diastolic blood pressure 88.1 ± 0.5 mmHg) with 288 age- and sex-matched normotensive controls.
Performed an oral glucose tolerance test after an overnight fast and 24-hour medication withdrawal, measuring plasma insulin and C-peptide at baseline and at 2 hours to calculate sum scores.
Hypertensive subjects had significantly higher insulin sums (0.69 ± 0.03 vs 0.41 ± 0.02) and C-peptide sums (3.36 ± 0.08 vs 2.74 ± 0.06) compared to normotensive controls (P<0.001 for both).
Multivariate analysis showed that the diagnosis of hypertension correlated with insulin sum (F=20.96, n=598, P<0.001) and C-peptide sum (F=6.68, P<0.01), whereas attained blood pressure levels did not.
Hypertensive patients receiving calcium antagonist monotherapy (n=21) exhibited lower insulin sums (0.45 ± 0.05) and C-peptide sums (2.63 ± 0.18) without differing in age or body mass index.

Structured PICO

Do well-controlled hypertensive subjects have higher insulin and C-peptide levels compared to normotensive controls?

Population

598 subjects from the Dalby population, comprising 310 subjects with well-controlled hypertension for >5 years (DBP <90 mmHg) and 288 age- and sex-matched normotensive controls.

Intervention

Diagnosis of treated hypertension

Comparator

Normotensive controls

Outcome

Insulin sum (P-insulin at start + after 2h of oral glucose tolerance test) and C-peptide sumsurrogate

Well-controlled hypertensive patients continue to exhibit hyperinsulinaemia and hyper-C-peptidaemia compared to normotensive controls, suggesting the metabolic disturbance is linked to the diagnosis rather than attained blood pressure.

Cite This Study

Nilsson et al. (1990) studied this question.

synapsesocial.com/papers/6a7ff5282cf87dafd7c85a3f https://doi.org/10.1097/00004872-199010000-00011

Topics

Hypertension management

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October 1, 1990Journal of Hypertension

Hyperinsulinaemia and other metabolic disturbances in well-controlled hypertensive men and women: an epidemiological study of the Dalby population

View Full Paper

Ask AI

Bookmark

Why the study?

Do well-controlled hypertensive subjects have higher insulin and C-peptide levels compared to normotensive controls?

Population

598 subjects from the Dalby population, comprising 310 subjects with well-controlled hypertension for >5…

Comparison

Diagnosis of treated hypertension vs Normotensive controls

Design

Cross-sectional

Authors

PNPeter NilssonScience for Life Laboratory LLLars LindholmPreventive Cardiology BNBengt Scherst nLund University

Discussion

Member takes

Implication

Persistent hyperinsulinemia despite BP control should not alter targets; leaves open causal links to outcomes in longitudinal studies.

Key Points

To determine whether hyperinsulinaemia and related metabolic disturbances persist in patients with well-controlled hypertension compared to normotensive controls.
Conducted an epidemiological matched case-control study comparing 310 patients with hypertension for >5 years (diastolic blood pressure 88.1 ± 0.5 mmHg) with 288 age- and sex-matched normotensive controls.
Performed an oral glucose tolerance test after an overnight fast and 24-hour medication withdrawal, measuring plasma insulin and C-peptide at baseline and at 2 hours to calculate sum scores.
Hypertensive subjects had significantly higher insulin sums (0.69 ± 0.03 vs 0.41 ± 0.02) and C-peptide sums (3.36 ± 0.08 vs 2.74 ± 0.06) compared to normotensive controls (P<0.001 for both).
Multivariate analysis showed that the diagnosis of hypertension correlated with insulin sum (F=20.96, n=598, P<0.001) and C-peptide sum (F=6.68, P<0.01), whereas attained blood pressure levels did not.
Hypertensive patients receiving calcium antagonist monotherapy (n=21) exhibited lower insulin sums (0.45 ± 0.05) and C-peptide sums (2.63 ± 0.18) without differing in age or body mass index.

Structured PICO

Do well-controlled hypertensive subjects have higher insulin and C-peptide levels compared to normotensive controls?

Population

598 subjects from the Dalby population, comprising 310 subjects with well-controlled hypertension for >5 years (DBP <90 mmHg) and 288 age- and sex-matched normotensive controls.

Intervention

Diagnosis of treated hypertension

Comparator

Normotensive controls

Outcome

Insulin sum (P-insulin at start + after 2h of oral glucose tolerance test) and C-peptide sumsurrogate

Cite This Study

Nilsson et al. (1990) studied this question.

synapsesocial.com/papers/6a7ff5282cf87dafd7c85a3f https://doi.org/10.1097/00004872-199010000-00011

Also Consider

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Topics

Hypertension management

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