Population
31 subjects: 21 hypertensive patients and 10 age- and sex-matched healthy controls.
Comparison
In vitro stimulation of isolated T-lymphocytes… vs Unstimulated T-lymphocytes and T-lymphocytes…
Design
Case-control
Authors
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Observational link between inflammation and amplified RAS response in hypertension; hypothesis-generating and should not yet alter practice.
In hypertensive patients, T-cell renin-angiotensin system activation is driven by Angiotensin II and amplified by low-grade inflammation, correlating with target organ damage.
Coppo et al. (2011) studied this question.
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