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August 15, 2026The American Journal of Chinese Medicine

Panax quinquefolius saponins promote post-MI angiogenesis by binding DNMT3b and activating the Notch1/USP5/STAT3 axis.

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Why the study?

Panax quinquefolius saponins (PQS) have cardiovascular benefits, but their epigenetic mechanisms in post-myocardial infarction angiogenesis remain unclear.

Population

Male C57BL/6 mice with LAD ligation and hypoxic HUVECs

Comparison

Panax quinquefolius saponins vs control

Design

Preclinical animal and in vitro laboratory study

Key result

Panax quinquefolius saponins, particularly ginsenoside Rc, promoted angiogenesis following myocardial infarction by directly binding DNMT3b and activating the Notch1/USP5/STAT3 signaling axis.

Authors

JYJun-Han YaoYBYu BiGBGang-Tao Bu

Discussion

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Overview

Should not yet change post-MI practice; leaves open human translation of this novel DNMT3b–Notch1 angiogenic axis.

Key Points

  • To investigate the epigenetic mechanisms and angiogenic efficacy of Panax quinquefolius saponins following myocardial infarction.
  • Myocardial infarction was induced in male C57BL/6 mice via left anterior descending coronary artery ligation and evaluated using histopathology and echocardiography.
  • Endothelial cell migration, capillary tube formation, and protein expression were analyzed in hypoxic human umbilical vein endothelial cells.
  • Target interactions and epigenetic regulation were evaluated via network pharmacology, bisulfite sequencing PCR, Western blot, cellular thermal shift assays, and co-immunoprecipitation.
  • Panax quinquefolius saponins directly bound DNMT3b, reversing aberrant DNA methylation at the Notch1 promoter and activating the Notch1/USP5/STAT3 signaling axis.
  • Treatment enhanced endothelial cell migration, tube formation, and in vivo angiogenesis in post-infarction models.
  • Ginsenoside Rc, ginsenoside Rh4, and vinaginsenoside R1 were identified as the primary active constituents, with ginsenoside Rc exhibiting the strongest DNMT3b affinity and angiogenic potency.

Structured PICO

P
Population
Male C57BL/6 mice with LAD ligation-induced myocardial infarction and hypoxic HUVECs.
I
Intervention
Panax quinquefolius saponins (PQS) and specific active components (ginsenoside Rc, ginsenoside Rh4, and vinaginsenoside R1)
O
Outcome
Angiogenesis, endothelial cell migration, tube formation, and therapeutic effects on MI (assessed by histopathological staining and echocardiography)surrogate

Panax quinquefolius saponins, particularly ginsenoside Rc, promote post-MI angiogenesis via epigenetic modulation of the DNMT3b/Notch1/USP5/STAT3 axis in preclinical models.

Cite This Study

Yao et al. (2026) studied Myocardial infarction. Panax quinquefolius saponins (PQS) was evaluated on Angiogenesis, endothelial cell migration, and tube formation. Panax quinquefolius saponins, particularly ginsenoside Rc, promoted angiogenesis following myocardial infarction by directly binding DNMT3b and activating the Notch1/USP5/STAT3 signaling axis.

synapsesocial.com/papers/6a8019bb75c2e31742c85d4fhttps://doi.org/10.1142/s0192415x26500680
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1LC-MS Analysis of Ginsenosides in Different Parts of Panax quinquefolius and Their Potential for Coronary Disease Improvement2023 · 10 citations
  2. 2Panaxquin quefolium diolsaponins dose-dependently inhibits the proliferation of vascular smooth muscle cells by downregulating proto-oncogene expression2013 · 4 citations
  3. 3Qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway2024 · 2 citations
  4. 4Panax Quinquefolius Saponin of Stem and Leaf Attenuates Intermittent High Glucose-Induced Oxidative Stress Injury in Cultured Human Umbilical Vein Endothelial Cells via PI3K/Akt/GSK-3βPathway2013 · 21 citations
  5. 5Shenqi Granules Enhance Recovery from Myocardial Ischemia–Reperfusion Injury by Downregulating MMP9 and ADH1C2026