Key result
Panax quinquefolium diolsaponins suppress AngII-induced VSMC proliferation by downregulating proto-oncogenes.
Why the study?
The proliferation of vascular smooth muscle cells plays an important role in coronary heart disease and restenosis after PCI, and the potential effect of Panax quinquefolium diolsaponins on this proliferation was investigated.
Population
Isolated rat vascular smooth muscle cells
Comparison
Panax quinquefolium diolsaponins vs angiotensin II-induced proliferation
Design
In vitro experimental study with immunocytochemical analysis and flow cytometry
Authors
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Hypothesis-generating for atherosclerosis prevention; leaves open translation from animal models to patients.
PQDS inhibits AngII-induced proliferation of vascular smooth muscle cells, suggesting a potential mechanism for preventing atherosclerosis.
Zhao et al. (2013) studied Angiotensin II-induced vascular smooth muscle cell proliferation. Panax quinquefolium diolsaponins (PQDS) vs. Angiotensin II alone was evaluated on Cell proliferation and proto-oncogene expression. Panax quinquefolium diolsaponins significantly suppressed AngII-induced vascular smooth muscle cell proliferation in a dose-dependent manner by downregulating proto-oncogene expression.
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