Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 30, 2026˜Die œPharmazieOpen Access

In vivo and in vitro cardioprotective effects of Panax quinquefolium 20 (S)-protopanaxadiol saponins (PQDS), isolated from Panax quinquefolium

View Full Paper
Ask AI
Bookmark
Share

Authors

HXHuali XuXYXiaofeng YuSQShaochun Qu

Discussion

Loading...

Member takes

Overview

In vivo and in vitro results show PQDS reduces cardiac injury and improves heart function post-infarction, indicating antioxidant potential.

Key Points

  • This study aims to evaluate the cardioprotective effects of Panax quinquefolium saponins in acute myocardial infarction.
  • Used Sparague Dawley rats for in vivo myocardial infarction model.
  • Investigated cytoprotective effects of PQDS on neonatal rat cardiomyocytes.
  • Performed histopathological assessments alongside biochemical evaluations of serum levels.
  • PQDS treatment reduced infarct size from 20.87% to 14.87%.
  • Decreased levels of cardiac injury markers: CK-MB, LDH, and ALT.
  • Increased activity of heart antioxidants like superoxide dismutase and glutathione peroxidase.

Cite This Study

Xu et al. (2013) studied this question.

synapsesocial.com/papers/69f2a42a8c0f03fd6776327fhttps://doi.org/10.31083/ph.2013.2752
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuative role of didymin against paraquat prompted cardiotoxicity in albino rats2024 · 6 citations
  2. 2Protective Effect of Saponins from Panax notoginseng against Doxorubicin-Induced Cardiotoxicity in Mice2008 · 33 citations
  3. 3Promotion of Angiogenesis with American Ginseng ( <i>Panax quinquefolius</i> ) After Myocardial Infarction via Targeting DNMT3b-Mediated DNA Methylation and Activating the Notch1/USP5/STAT3 Signaling Axis2026
  4. 4Blackened Panax quinquefolius L. Saponins and Their Cytotoxic Effect on HepG2 Cells2026
  5. 5Panaxadiol Saponin alleviates LPS-induced cardiomyopathy similar to dexamethasone via improving mitochondrial quality control2024 · 4 citations