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April 3, 2026MoleculesOpen Access

Blackened Panax quinquefolius L. Saponins and Their Cytotoxic Effect on HepG2 Cells

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Authors

YTYuanyuan TianJGJiaqi GaoYLYongqi Liu

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Overview

This work investigates the cytotoxic effects of blackened Panax quinquefolius saponins on HepG2 cells, indicating potential as a dietary supplement.

Key Points

  • To explore the cytotoxic effects of blackened Panax quinquefolius saponins on HepG2 cells and assess ginsenoside transformations during processing.
  • Investigated blackening process at temperatures of 70–90 °C and humidities of 70–85% over 0–14 days.
  • Analyzed ginsenoside compositions using high-performance liquid chromatography (HPLC).
  • Measured antioxidant activity using DPPH and ABTS+ radical scavenging assays.
  • Evaluated cytotoxicity and apoptosis-related protein expression in HepG2 cells.
  • Blackening increased total saponin content from 2.72% to 5.73% after optimal treatment conditions.
  • BPQS exhibited stronger antioxidant activities with IC50 values of 0.2999 mg/mL for DPPH and 0.2640 mg/mL for ABTS+.
  • BPQS showed higher cytotoxic effects on HepG2 cells, promoting apoptosis through increased expression of caspase 3 and 9.

Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/69cf5dd55a333a821460bcf3https://doi.org/10.3390/molecules31071173
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  2. 2In vivo and in vitro cardioprotective effects of Panax quinquefolium 20 (S)-protopanaxadiol saponins (PQDS), isolated from Panax quinquefolium2013
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