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Review the quantitative and qualitative deterioration of T cells during aging and highlight emerging therapeutic strategies to rejuvenate T-cell function for healthy aging.

August 15, 2026International Immunology

Healthy ageing: The struggle for maintaining T cells young

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Authors

DFDavid FrieserCentre National de la Recherche Scientifique NGN. GensousCentre National de la Recherche Scientifique VAVictor AppayCentre National de la Recherche Scientifique

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Implication

Review uncovers mechanisms of age-related T-cell decline in older populations, highlighting emerging therapeutic strategies for immune rejuvenation.

Key Points

Review the quantitative and qualitative deterioration of T cells during aging and highlight emerging therapeutic strategies to rejuvenate T-cell function for healthy aging.
Narrative review examining cellular and molecular literature on age-related changes across the immune system, with a specific focus on the T-cell compartment.
Synthesis of pathophysiological mechanisms driving inflammaging and evaluation of experimental strategies for T-cell preservation and rejuvenation.
The T-cell compartment undergoes the most substantial quantitative and qualitative functional decline of all immune subsets during aging.
Age-associated pathophysiological factors accelerate T-cell dysfunction and drive chronic inflammaging, compounding cancer incidence and infection susceptibility.
Recent advances identify targeted molecular and cellular rejuvenation strategies capable of restoring T-cell fitness and promoting healthy aging.

Cite This Study

Frieser et al. (2026) studied this question.

synapsesocial.com/papers/6a801a1a75c2e31742c868ee https://doi.org/10.1093/intimm/dxag042

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Implication

Review uncovers mechanisms of age-related T-cell decline in older populations, highlighting emerging therapeutic strategies for immune rejuvenation.

Healthy ageing: The struggle for maintaining T cells young

Discussion

Member takes

Implication

Key Points

Cite This Study

Healthy ageing: The struggle for maintaining T cells young

Discussion

Member takes

Implication

Key Points

Cite This Study

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