Why the study?
The nepmucin Arg82Cys variant associates with lower fasting HDLc and higher fasting triglycerides, but its link to postprandial lipids and glycemic status remained elusive.
Does the Arg82Cys polymorphism in nepmucin affect fasting HDL subclasses, postprandial lipemia, and glycemic status in healthy individuals?
Population
4522 healthy men and women from Oxford BioBank and participants in recall-by-genotype studies
Comparison
Arg82Cys polymorphism carriers vs noncarriers
Design
Population-based cohort study and recall-by-genotype studies
Authors
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Cys82 polymorphism associated with lower large HDL cholesterol; hypothesis-generating for nepmucin’s role in HDL metabolism.
Does the Arg82Cys polymorphism in nepmucin affect fasting HDL subclasses, postprandial lipemia, and glycemic status in healthy individuals?
The Arg82Cys variant in nepmucin is associated with lower concentrations of large HDL particles and ApoA1, suggesting a role in HDL metabolism and maturation.
Metz et al. (2022) studied this question.
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