Key result
An ECG-gated CT cardiac motion estimation method showed clinical target volumes moved 3.4 ± 1.4 mm and ICD lead tips moved 4.9 ± 2.2 mm, with strong 3D motion correlation (PCC 0.84).
Why the study?
Heartbeat-induced motion is essential to define an appropriate cardiac internal target volume margin during stereotactic arrhythmia radioablation for refractory ventricular tachycardia.
Cohort (n=10)
Effect estimate: PCC 0.84
ECG-gated cardiac CT enables patient- and segment-specific cardiac internal target volume margin estimation for stereotactic arrhythmia radioablation.
Supports patient-specific cardiac ITV planning in STAR but should not yet change practice; leaves open dosimetric effects of residual heartbeat motion.
Background and purpose: Motion management strategies such as gating under breath-hold can reduce breathing-induced motion during stereotactic arrhythmia radioablation (STAR) for refractory ventricular tachycardia. However, heartbeat-induced motion is essential to define an appropriate cardiac internal target volume (ITV) margin. In this study, we introduce a patient- and segment-specific cardiac motion estimation method and cardiac motion data of the clinical target volume (CTV), ICD lead tips and left ventricle (LV) segments. Materials and methods: Data from 10 STAR-treated patients were retrospectively analyzed. The LV was semi-automatically segmented according to the 17-segment model. Electrocardiogram-gated contrast-enhanced breath-hold cardiac CTs were automatically non-rigidly registered for motion estimation. The correlation and significant differences between ICD tip motion and CTV motion were assessed using the Pearson correlation coefficient (PCC) and Wilcoxon signed-rank test, while spatial discrepancies with both CTV and segment motion were quantified using the Euclidean distance. Results: The CTVs (center of mass) moved 3.4 ± 1.4 mm and the ICD lead tips moved 4.9 ± 2.2 mm. The maximum motion per patient was observed in basal and mid-cavity LV segments in 3D. The PCC showed a strong positive motion correlation between the ICD tip and CTV in 3D (0.84), while the p-values indicated statistically significant differences in the right-left, anterior-posterior and 3D directions. Conclusion: The proposed methods enable patient- and segment-specific cardiac ITV margin estimation. The motion in most LV segments was limited, however, cardiac ITV margins may need adjustment in individual cases. The impact of cardiac motion on the dosimetry needs further investigation.
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Xie et al. (2025) conducted a cohort in Refractory ventricular tachycardia (n=10). Electrocardiogram-gated cardiac computed tomography-based cardiac motion estimation was evaluated on Motion of the clinical target volume (CTV) and ICD lead tips (PCC 0.84). An ECG-gated CT cardiac motion estimation method showed clinical target volumes moved 3.4 ± 1.4 mm and ICD lead tips moved 4.9 ± 2.2 mm, with strong 3D motion correlation (PCC 0.84).
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