Why the study?
Does celecoxib cause ischemic complications in patients with connective tissue diseases predisposed to thrombosis?
Population
4 patients with connective tissue diseases with a history of Raynaud's phenomenon, elevated anticardiolipin…
Design
Case_series
Authors
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May signal ischemic risk with celecoxib in prothrombotic connective tissue disease; hypothesis-generating and leaves causality open.
Does celecoxib cause ischemic complications in patients with connective tissue diseases predisposed to thrombosis?
COX-2 inhibitors like celecoxib may trigger ischemic complications in patients with connective tissue diseases who have underlying prothrombotic predispositions.
Crofford et al. (2000) studied this question.
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