Why the study?
Are arterial stiffness and endothelial function altered in patients with beta-thalassemia major compared to healthy controls?
Population
30 patients with beta-thalassemia major (16 male, aged 22.2+/-7.4 years) and 30 age- and sex-matched controls.
Design
Case-control
Authors
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Arterial stiffness and endothelial dysfunction are associated with beta-thalassemia major; leaves open their contribution to cardiovascular risk and need for prospective validation.
Are arterial stiffness and endothelial function altered in patients with beta-thalassemia major compared to healthy controls?
Patients with beta-thalassemia major exhibit increased arterial stiffness, endothelial dysfunction, and left ventricular hypertrophy, which may contribute to cardiovascular risk.
Cheung et al. (2002) studied this question.
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