December 27, 2016Journal of Cardiovascular Translational ResearchOpen Access

In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)

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Why the study?

Does the novel TRISKELE transcatheter heart valve improve hydrodynamic performance and reduce paravalvular leakage compared to commercial TAVI valves in an in vitro model?

Population

In vitro mock silicone aortic roots of 21, 23, 25, and 27 mm annulus diameter in a cardiovascular…

Comparison

TRISKELE transcatheter aortic valve featuring… vs Commercially available TAVI valves: Edwards…

Design

Preclinical

Authors

BRBenyamin RahmaniUniversity College London STSpyros TzamtzisUniversity College London RSRose SheridanAllegheny College

Discussion

Member takes

Implication

Supports further preclinical testing of TRISKELE valves; leaves open clinical translation.

Structured PICO

Does the novel TRISKELE transcatheter heart valve improve hydrodynamic performance and reduce paravalvular leakage compared to commercial TAVI valves in an in vitro model?

Population

In vitro mock silicone aortic roots of 21, 23, 25, and 27 mm annulus diameter in a cardiovascular pulse-duplicator system

Intervention

TRISKELE transcatheter aortic valve (sizes 23, 26, and 29 mm) featuring polymeric leaflets and an adaptive sealing cuff on a self-expanding nitinol wire frame

Comparator

Commercially available TAVI valves: Edwards SAPIEN XT and Medtronic CoreValve (n=1 per size)

Outcome

Hydrodynamic performance including mean transvalvular systolic pressure drop, effective orifice area, regurgitant fraction, and fluid-mechanical left ventricular energy losssurrogate

The novel TRISKELE transcatheter heart valve with polymeric leaflets demonstrated promising in vitro hydrodynamic performance and reduced paravalvular leakage compared to current commercial devices, supporting further preclinical investigation.

Limitations

Isotonic saline was used as testing fluid, which is less viscous than blood and may affect leakage flow
Lack of statistical power due to minimal number of reference devices (n=1 per size)
Absence of calcific or fibrotic lesions in the in vitro test model

Cite This Study

Rahmani et al. (2016) studied this question.

synapsesocial.com/papers/6a809ef59fb6070370caec08 https://doi.org/10.1007/s12265-016-9722-0

Topics

Transcatheter aortic valve replacement TAVR in low-risk patients

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In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE)

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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