Key result
In individuals with hypertension, a history of major depressive disorder significantly increased the risk of first-onset adverse cardiovascular outcomes compared to hypertension alone (HR 1.22; 95% CI 1.1-1.35).
Why the study?
It was unclear whether a history of major depressive disorder in middle-aged individuals with hypertension influences first-onset cardiovascular disease outcomes.
Does comorbid major depressive disorder increase the risk of first-onset cardiovascular disease outcomes in middle-aged individuals with hypertension?
Cohort (n=134,860)
Yes
Does comorbid major depressive disorder increase the risk of first-onset cardiovascular disease outcomes in middle-aged individuals with hypertension?
Hazard Ratio: 1.22 (95% CI 1.1–1.35)
Comorbid major depressive disorder and hypertension confers a significantly greater risk of adverse cardiovascular outcomes than hypertension alone, suggesting depression history should be incorporated into cardiovascular risk prediction.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice in hypertension; leaves open adding MDD history to first-event CV risk scores.
Graham et al. (2019) conducted a cohort in Hypertension and Major Depressive Disorder (n=134,860). Major depressive disorder (MDD) vs. Hypertension alone was evaluated on First-onset adverse cardiovascular outcomes leading to hospital admission or death (HR 1.22, 95% CI 1.1-1.35). In individuals with hypertension, a history of major depressive disorder significantly increased the risk of first-onset adverse cardiovascular outcomes compared to hypertension alone (HR 1.22; 95% CI 1.1-1.35).
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