Key result
Thrombin activatable fibrinolysis inhibitor (TAFI) is a key protein regulating fibrinolysis and inflammation, with significant roles in thrombosis, bleeding disorders, and pregnancy complications.
This review highlights the biological effects and clinical significance of TAFI in regulating fibrinolysis and its potential as a therapeutic target or biomarker in various thrombotic, inflammatory, and obstetric conditions.
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I need the paper's actual verdict and full abstract before writing the implication. Searching now.The page is a narrative review, not a trial. Fetching the full text to pin down the actual verdict.TAFI-directed therapy should not yet change practice; leaves open whether pharmacologic or genotype-guided TAFI modulation improves outcomes.
Thrombin activatable fi brinolysis inhibitor (TAFI) is one of the key proteins of fi brinolysis and infl ammation systems. Based on literature data, information is presented on the biological eff ects of TAFI, the mechanisms of its activation, gene polymorphism that determines the duration of its action and activity. Nosological forms are listed, where TAFI is important in the pathogenesis of the development of diseases, its role in experimental and laboratory studies, and the possibility of pharmacological infl uence on the activity of this protein.
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Бокарев et al. (2023) conducted a review in Thrombosis, bleeding disorders, and pregnancy complications. Thrombin activatable fibrinolysis inhibitor (TAFI) was evaluated. Thrombin activatable fibrinolysis inhibitor (TAFI) is a key protein regulating fibrinolysis and inflammation, with significant roles in thrombosis, bleeding disorders, and pregnancy complications.
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