Key result
Higher intracoronary TAFI levels linked to CAD.
Why the study?
Are TAFI antigen levels associated with the presence of coronary artery disease in patients undergoing angiography?
Population
496 subjects investigated by angiography, comprising 362 patients with coronary artery disease and 134…
Comparison
Measurement of Thrombin Activatable Fibrinolysis… vs Control subjects free of CAD
Design
Case-control
Authors
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Elevated intracoronary TAFI was associated with CAD; hypothesis-generating and requires prospective validation before clinical consideration.
Case-Control (n=496)
Are TAFI antigen levels associated with the presence of coronary artery disease in patients undergoing angiography?
Elevated intracoronary TAFI levels are associated with the presence of coronary artery disease, suggesting a potential role in inflammation and CAD development.
Schroeder et al. (2002) conducted a case-control in Coronary artery disease (n=496). Thrombin Activatable Fibrinolysis Inhibitor (TAFI) levels vs. Control subjects free of CAD was evaluated on TAFI antigen levels in venous and intracoronary plasma samples. Intracoronary TAFI levels were significantly higher in patients with coronary artery disease compared to controls, suggesting TAFI may be a risk factor for CAD development.
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