May 1, 2000Blood
Thrombin activatable fibrinolysis inhibitor and the risk for deep vein thrombosis
Why the study?
Do elevated TAFI levels increase the risk for deep vein thrombosis?
Population
948 subjects from the Leiden Thrombophilia Study.
Comparison
Elevated TAFI levels vs TAFI levels below the 90th percentile
Design
Case-control
Authors
Discussion
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Member takes
Implication
May support TAFI as mild DVT risk marker in targeted cases; leaves open causal role and clinical utility.
Key Points
- To determine whether elevated plasma levels of thrombin activatable fibrinolysis inhibitor (TAFI) confer a hypofibrinolytic state that increases the risk of venous thrombosis.
- Assessed plasma TAFI antigen concentrations using an electroimmunoassay in the Leiden Thrombophilia Study, a case-control study including 474 patients with a first deep vein thrombosis and 474 age- and sex-matched controls.
- Evaluated associations between TAFI levels, age, sex, oral contraceptive use, and thrombotic risk, adjusting for potential confounding variables.
- Plasma TAFI levels above the 90th percentile of controls (> 122 U/dL) were associated with a nearly two-fold increased risk of thrombosis (OR, 1.7; 95% CI, 1.1-2.5).
- Elevated TAFI levels were present in 14% of patients with deep vein thrombosis versus 9% of healthy controls, with levels increasing with age in women and with oral contraceptive use.
- High TAFI levels did not amplify the thrombotic risk associated with factor V Leiden, though evidence suggested a possible interaction with elevated factor VIII levels.
Structured PICO
Do elevated TAFI levels increase the risk for deep vein thrombosis?
P
Population
948 subjects (474 patients with a first deep vein thrombosis and 474 age- and sex-matched healthy control subjects) from the Leiden Thrombophilia Study.
I
Intervention
Elevated TAFI levels (> 122 U/dL, above the 90th percentile of controls)
C
Comparator
TAFI levels below the 90th percentile
O
Outcome
Risk for venous thrombosis (first deep vein thrombosis)hard clinical
Elevated TAFI levels (> 122 U/dL) are a mild risk factor for a first deep vein thrombosis, increasing the risk nearly 2-fold.
Cite This Study
Tilburg et al. (2000) studied this question.