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September 2, 2003Stroke

Risk of Ischemic Stroke Associated With Functional Thrombin-Activatable Fibrinolysis Inhibitor Plasma Levels

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Authors

ASAmparo SantamaríaFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana AOArturo OliverUniversitat Autònoma de Barcelona MBM. BorrellHospital Sant Joan de Déu Barcelona

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Implication

Case-control study reveals elevated functional thrombin-activatable fibrinolysis inhibitor levels increase ischemic stroke risk in adults, suggesting a target for therapeutic intervention.

Key Points

To evaluate whether elevated plasma levels of functional thrombin-activatable fibrinolysis inhibitor (TAFI) correlate with an increased risk of ischemic stroke.
Conducted a case-control study with 264 participants, including 114 patients with ischemic stroke and 150 age- and sex-matched controls with no history of arterial disease.
Quantified functional TAFI activity via activation with thrombin-thrombomodulin, and evaluated other hemostatic factors including factor VIIIc, fibrinogen, and prothrombotic mutations.
Functional TAFI levels were significantly elevated in patients with ischemic stroke compared to controls (113.7 ± 25%, range 57%–209% vs. 102.6 ± 19%).
Plasma functional TAFI levels >120% were strongly associated with ischemic stroke risk, conferring an odds ratio of 5.7 (95% CI, 2.3–14.1).

Cite This Study

Santamaría et al. (2003) studied this question.

synapsesocial.com/papers/6a80acf1ea50fa4f0792a153 https://doi.org/10.1161/01.str.0000088642.07691.15

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Implication

Case-control study reveals elevated functional thrombin-activatable fibrinolysis inhibitor levels increase ischemic stroke risk in adults, suggesting a target for therapeutic intervention.

Risk of Ischemic Stroke Associated With Functional Thrombin-Activatable Fibrinolysis Inhibitor Plasma Levels

Discussion

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Implication

Key Points

Cite This Study

Risk of Ischemic Stroke Associated With Functional Thrombin-Activatable Fibrinolysis Inhibitor Plasma Levels

Discussion

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Implication

Key Points

Cite This Study

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