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January 29, 2014Journal of Cardiovascular Pharmacology

Signaling via P2Y12 May Be Critical for Early Stabilization of Platelet Aggregates

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Population

Human platelets in vitro and a murine arterial thrombosis model (FeCl3-induced occlusion) in vivo (n=3)

Comparison

Ticagrelor administered in vitro to platelet… vs Drug carrier control / vehicle control

Design

Preclinical

Follow-up

30 minutes

Authors

HSHenry E. SpeichVBVinay BhalKHKourtney Houser

Discussion

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Overview

Ticagrelor may reverse early thrombus in animals; hypothesis-generating and should not yet alter clinical practice.

Structured PICO

P
Population
Human platelets in vitro and a murine arterial thrombosis model (FeCl3-induced occlusion) in vivo (n=3)
I
Intervention
Ticagrelor (reversible P2Y12 antagonist) administered in vitro to platelet aggregates or as an intravenous bolus in vivo
C
Comparator
Drug carrier control / vehicle control
O
Outcome
Platelet aggregate stability (in vitro) and extent of arterial thrombus reversal measured by Doppler blood flow and thrombus size (in vivo)surrogate

Ticagrelor disrupts newly formed platelet aggregates and partially reverses early arterial thrombotic occlusion, highlighting the role of P2Y12 signaling in stabilizing platelet thrombi.

Cite This Study

Speich et al. (2014) studied this question.

synapsesocial.com/papers/6a80b68e1c96fcc8ad70445ahttps://doi.org/10.1097/fjc.0000000000000076
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Also Consider

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  1. 1Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors2011 · 49 citations
  2. 2Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers2010 · 145 citations
  3. 3The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide1987 · 1,174 citations
  4. 4Heart Disease and Stroke Statistics—2012 Update2011 · 7,240 citations
  5. 5Ticagrelor: The First Reversibly Binding Oral P2Y<sub>12</sub> Receptor Antagonist2009 · 339 citations