Early-term heterogeneous trajectories of patient-reported outcome undergoing percutaneous coronary intervention: a multicenter and prospective longitudinal study

AIMS: To explore the longitudinal trajectories of patient-reported outcome (PRO) and identify variables associated with these trajectories in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS AND RESULTS: This multicenter, prospective, longitudinal cohort study assessed the health status of PCI patients using the patient-reported outcome instruments for chronic disease-coronary heart disease at baseline, 7 days, 1 month, and 3 months post-operatively. Baseline characteristics were collected through general information questionnaires. Growth mixture modelling (GMM) was applied to estimate PRO trajectories and logistic regression analyses were used to identify their predictors. A total of 353 patients were included in the analysis, revealing three distinct PRO trajectory classes: moderate-level rapid recovery group (86.4%), low-level slow recovery group (5.10%), and high-level continuous deterioration group (8.50%). Logistic regression identified living status, admission diagnosis, diabetes, sleep medications history, and sleep quality as significant predictors for those trajectories. CONCLUSION: Patient-reported outcome trajectories within 3 months post-PCI show considerable heterogeneity, influenced by a range of disease-specific, healthy lifestyle, and sociodemographic factors. These findings underscore the importance of personalized, targeted interventions to optimize patient health outcomes.