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May 22, 2021BMC Endocrine DisordersOpen Access

Age (OR 1.089, 95% CI 1.055-1.123, p<0.001), previous use of RASIs (OR 2.330, 95% CI 1.212-4.481, p=0.011), and HbA1c (OR 0.839, 95% CI 0.716-0.983, p=0.03) were independent risk factors for NADKD.

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Why the study?

Normoalbuminuric diabetic kidney disease is a newly defined entity whose clinical features and pathogenesis are still being understood.

Population

1620 hospitalized patients with type 2 diabetes mellitus

Comparison

Four groups based on presence or absence of albuminuria and reduced eGFR

Design

Retrospective cross-sectional study

Authors

QDQi DaiNCNan ChenLZLing Zeng

Discussion

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Member takes

Overview

May flag high-CV-risk NADKD in older well-controlled T2DM on RASIs; leaves open distinct mechanisms and whether practice should change.

Structured PICO

P
Population
1,620 hospitalized patients with type 2 diabetes mellitus, mean age 57.0, 34.4% female, in China. Exclusions included type 1 diabetes, ketoacidosis, hyperosmolar coma, acute infection, pregnancy, acute cardiovascular/cerebrovascular diseases, and other types of nephropathy.
O
Outcome
Risk factors for normoalbuminuric diabetic kidney disease (NADKD)

Normoalbuminuric diabetic kidney disease in type 2 diabetes is independently associated with older age, previous use of renin-angiotensin system inhibitors, and lower HbA1c, and is linked to a higher prevalence of macrovascular complications.

Cite This Study

Dai et al. (2021) studied this question.

synapsesocial.com/papers/6a80c741aebadc726571df06https://doi.org/10.1186/s12902-021-00769-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence of normoalbuminuric chronic kidney disease among individuals with type 2 diabetes mellitus from India2022 · 9 citations
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  5. 5Diabetic kidney disease in patients newly diagnosed with type-2 diabetes mellitus: Incidence and associations2020 · 24 citations