Why the study?
Does intravenous Escherichia coli endotoxin decrease the plasma L-arginine/ADMA ratio in healthy males?
Does intravenous Escherichia coli endotoxin decrease the plasma L-arginine/ADMA ratio in healthy males?
Acute experimental inflammation induced by endotoxin decreases the L-arginine/ADMA ratio, which may contribute to impaired vascular function.
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Endotoxin challenge lowers the L-arginine/ADMA ratio in healthy volunteers; establishes causal evidence linking acute inflammation to endothelial impairment.
Mittermayer et al. (2004) studied this question.