Why the study?
Does cell swelling alter delayed rectifier potassium currents (IKr and IKs) in guinea pig cardiac myocytes?
Population
Single guinea pig cardiac myocytes
Comparison
Hypoosmotic solution causing cell swelling vs Isoosmotic conditions (300 mOsm)
Design
Preclinical
Authors
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May contribute to ischemia-reperfusion arrhythmogenesis; leaves open human relevance pending further study.
Does cell swelling alter delayed rectifier potassium currents (IKr and IKs) in guinea pig cardiac myocytes?
Cell swelling has differential effects on delayed rectifier potassium currents, increasing IKs and decreasing IKr, which may contribute to ischemia- and reperfusion-induced arrhythmogenesis.
Rees et al. (1995) studied this question.
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