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January 1, 2003Respiration

Laboratory Tests in the Diagnosis of Pulmonary Embolism

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Why the study?

What is the diagnostic and prognostic value of laboratory tests in patients with suspected pulmonary embolism?

Population

Patients with suspected pulmonary embolism

Design

Review

Authors

GMGuy MeyerVascular MedicinePRPierre Marie RoyCentre National de la Recherche ScientifiqueHSHervé SorsInstitut Pasteur

Discussion

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Implication

Supports D-dimer testing to exclude PE in low-moderate probability; leaves open prospective validation of BNP/troponin for risk stratification.

Structured PICO

What is the diagnostic and prognostic value of laboratory tests in patients with suspected pulmonary embolism?

P
Population
Patients with suspected pulmonary embolism
I
Intervention
Laboratory tests including D-dimer assays (Vidas, SimpliRED), blood gas analysis, alveolar dead space fraction, brain natriuretic peptide (BNP), and cardiac troponin
O
Outcome
Diagnostic accuracy (sensitivity and specificity) for pulmonary embolismsurrogate

Specific D-dimer assays are effective for ruling out pulmonary embolism in low-to-moderate probability patients, whereas cardiac biomarkers like BNP and troponin are valuable for prognostic risk stratification.

Cite This Study

Meyer et al. (2003) studied this question.

synapsesocial.com/papers/6a80eb70dc834c04ade19354https://doi.org/10.1159/000070056

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of a New, Rapid, and Quantitative D-Dimer Test in Patients with Suspected Pulmonary Embolism1998 · 119 citations
  2. 2Use of a Clinical Decision Rule in Combination With D-Dimer Concentration in Diagnostic Workup of Patients With Suspected Pulmonary Embolism2002 · 195 citations
  3. 3Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and <scp>d</scp>-dimer2001 · 1,446 citations
  4. 4Pulmonary embolism: interobserver agreement in the interpretation of conventional angiographic and DSA images in patients with nondiagnostic lung scan results.1996 · 70 citations
  5. 5Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). The PIOPED Investigators1990 · 376 citations