Serum sickness and acute renal failure after streptokinase therapy for myocardial infarction
Why the study?
Does streptokinase therapy cause serum sickness and acute renal failure in patients with pre-existing antibodies?
Population
1 patient with myocardial ischaemia and a previous history of a cellulitic infection of the leg, with…
Design
Case_report
Authors
Discussion
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Member takes
Implication
Alerts clinicians to possible streptokinase-associated serum sickness in sensitized patients; hypothesis-generating for cryoglobulin-mediated renal injury.
Structured PICO
Does streptokinase therapy cause serum sickness and acute renal failure in patients with pre-existing antibodies?
P
Population
1 patient with myocardial ischaemia and a previous history of a cellulitic infection of the leg, with pre-existing antibodies to streptokinase.
I
Intervention
Streptokinase therapy
O
Outcome
Development of serum sickness and acute renal failuresafety
Streptokinase therapy can induce immune complex-mediated serum sickness and acute renal failure in patients with pre-existing antibodies from prior streptococcal infections.
Cite This Study
Davies et al. (1990) studied this question.