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December 1, 1984European Heart Journal

Serum sickness complicating intravenous streptokinase therapy in acute myocardial infarction

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Key result

Streptokinase therapy for acute MI can trigger delayed serum sickness regardless of dose or route.

Why the study?

Serum sickness after streptokinase therapy in acute myocardial infarction may occur independently of dose or administration route and can complicate treatment.

Comparison

Early high dose intravenous streptokinase

Design

Case report

Authors

DAD. AlexopoulosNational and Kapodistrian University of AthensARA. E. G. RaineUppsala UniversitySCS. M. CobbeGlasgow Royal Infirmary

Discussion

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Implication

Serum sickness may occur after streptokinase independent of dose or route; leaves open incidence and relevance for intracoronary use.

Structured PICO

P
Population
1 patient with acute myocardial infarction
I
Intervention
Early high dose intravenous streptokinase
O
Outcome
Delayed serum sickness with transient renal impairmentsafety

Serum sickness can occur as a complication of streptokinase therapy for acute myocardial infarction, regardless of dose or route of administration.

Cite This Study

Alexopoulos et al. (1984) studied this question. Streptokinase therapy for acute myocardial infarction can be complicated by delayed serum sickness, which may occur independently of the dose or route of administration.

synapsesocial.com/papers/6ab89005ac13a6441eebfb8bhttps://doi.org/10.1093/oxfordjournals.eurheartj.a061602
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum sickness and acute renal failure after streptokinase therapy for myocardial infarction1990 · 41 citations
  2. 2Streptokinase morbidity — more common than previously recognised1992 · 11 citations
  3. 3High dose intravenous streptokinase in acute myocardial infarction--short and long term prognosis.1986 · 12 citations
  4. 4Immunoglobulin response to intravenous streptokinase in acute myocardial infarction.1991 · 72 citations
  5. 5Vasculitis complicating treatment with intravenous anisoylated plasminogen streptokinase activator complex in acute myocardial infarction.1988 · 38 citations