April 1, 1992Australian and New Zealand Journal of Medicine

Streptokinase morbidity — more common than previously recognised

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Population

8 patients treated for acute myocardial infarction

Design

Case_series

Authors

WSW. J. Siebert RARichard W. AyresUniversity of Iowa Hospitals and Clinics MBMark BullingUniversity of Derby

Discussion

Member takes

Implication

Delayed streptokinase reactions may prolong stays; case reports leave open incidence and causality in broader use.

Structured PICO

Population

8 patients treated for acute myocardial infarction

Intervention

Streptokinase

Outcome

Late uncommon adverse reactions (vasculitic rashes, abnormal renal and liver function tests, and a syndrome resembling adult respiratory distress syndrome)safety

Streptokinase use in acute myocardial infarction can lead to significant delayed morbidity from immune complex-like adverse reactions, which should be considered in treatment decisions.

Cite This Study

Siebert et al. (1992) studied this question.

synapsesocial.com/papers/6a910bb88b76b10fb073d952 https://doi.org/10.1111/j.1445-5994.1992.tb02791.x

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