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February 25, 2025Behavioural Brain ResearchOpen Access

Within two days following ascent to 3800 m, nearly all cognitive indicators exhibited impairment, but gradually improved from the 3rd day and largely recovered to the plain level on the 5th to 7th day, correlating with EEG frequency alterations.

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Why the study?

It remained unclear whether cognitive abilities are selectively impaired or what the temporal trends of cognitive function are during acute high-altitude exposure.

Does acute exposure to high altitude hypoxia impair cognitive function and alter EEG patterns in lowlanders?

Comparison

Acute exposure to 3800 m for 1 week vs remaining at 400 m

Design

Controlled cohort study

Follow-up

1 week

Authors

GZGuangchao ZhaoZLZhihong LuHNHuang Nie

Discussion

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Member takes

Overview

May warrant caution for early cognitive lapses at 3800 m; leaves open generalizability beyond this small, mostly male cohort.

Structured PICO

Does acute exposure to high altitude hypoxia impair cognitive function and alter EEG patterns in lowlanders?

P
Population
43 lowlanders, including an exposure group of 20 subjects (mean age 27.9 ± 3.08 years; 18 males) and a control group of 23 subjects (mean age 26.5 ± 3.17 years; 21 males).
I
Intervention
Acute exposure to 3800 m high altitude for 1 week.
C
Comparator
Control group remaining at 400 m altitude undergoing identical assessments.
O
Outcome
Cognitive functions and electroencephalogram (EEG) data assessed at baseline and during the acute phase (days 1, 2, 3, 5, 7).surrogate

Acute exposure to high altitude causes initial cognitive impairment and EEG alterations that largely recover after 5-7 days of acclimatization.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/6a80ff5c0914b5fb8de3cbdehttps://doi.org/10.1016/j.bbr.2025.115515
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Meta‐Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High‐Altitude Hypoxia2025
  2. 2COGNITIVE FUNCTIONS AT HIGH ALTITUDE1976
  3. 3Effects of chronic high-altitude exposure on memory function in indigenous highland junior high school students: behavioral and electroencephalographic evidence2026
  4. 4Temporal Effects of Hypoxia Exposure at High Altitudes on Compensatory Brain Function: Evidence from Functional Connectivity of Resting-State EEG Brain Networks2024 · 6 citations
  5. 5Effects of acute high‐altitude exposure on working memory: A functional near‐infrared spectroscopy study2022 · 26 citations