Antibody to Granulocyte Macrophage Colony–stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function After Myocardial Infarction in a Rat Coronary Artery Ligation Model

Robert S. Kellar; Jordan J. Lancaster; Hoang M. Thai; Elizabeth Juneman; Nicholle M. Johnson; Howard G. Byrne; Maribeth Stansifer; Reza Arsanjani; Mark Baer; Christopher Bebbington; Michael Flashner; Geoffrey Yarranton; Steven Goldman

doi:10.1097/fjc.0b013e318213258b

February 23, 2011Journal of Cardiovascular Pharmacology

Antibody to Granulocyte Macrophage Colony–stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function After Myocardial Infarction in a Rat Coronary Artery Ligation Model

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Why the study?

Does a monoclonal antibody to GM-CSF improve left ventricular function and reduce tissue macrophages in a rat coronary artery ligation model of myocardial infarction?

Structured PICO

Does a monoclonal antibody to GM-CSF improve left ventricular function and reduce tissue macrophages in a rat coronary artery ligation model of myocardial infarction?

P

Population

Rat coronary artery ligation model of myocardial infarction

I

Intervention

Monoclonal antibody to GM-CSF (5 mg/kg) initiated 24 hours before coronary artery ligation and continued every 3 days for 3 weeks

C

Comparator

Controls

O

Outcome

Cardiac function (LV ejection fraction, LV end systolic diameter, LV systolic pressure, LV end diastolic pressure, LV end diastolic diameter, time constant of LV relaxation tau) and tissue macrophage count/infarct size at 3 weeks postligationsurrogate

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Implication

Inhibition of GM-CSF improves left ventricular function and reduces macrophage infiltration in a rat model of myocardial infarction, suggesting a potential therapeutic target for post-MI heart failure.

Abstract

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Discussion

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Cite This Study

Kellar et al. (2011) studied this question.

synapsesocial.com/papers/6a81100dd7cc3676436601a6 https://doi.org/10.1097/fjc.0b013e318213258b

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Antibody to Granulocyte Macrophage Colony–stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function After Myocardial Infarction in a Rat Coronary Artery Ligation Model

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Antibody to Granulocyte Macrophage Colony–stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function After Myocardial Infarction in a Rat Coronary Artery Ligation Model

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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