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June 9, 2009CirculationOpen Access

DITPA (3,5-Diiodothyropropionic Acid), a Thyroid Hormone Analog to Treat Heart Failure

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Why the study?

Does DITPA improve a composite endpoint of symptoms and morbidity/mortality in patients with NYHA class II to IV congestive heart failure?

Population

86 patients with New York Heart Association (NYHA) class II to IV congestive heart failure

Comparison

DITPA treated for 6 months vs Placebo

Design

RCT, 2:1 to DITPA or placebo, double-blind

Follow-up

6 months

Authors

SGSteven GoldmanHeart Failure & TransplantMMMadeline McCarrenEdward Hines, Jr. VA HospitalEMEugene MorkinUniversity of Arizona

Discussion

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Implication

DITPA should not be used in heart failure; challenges reliance on hemodynamic surrogates for symptomatic benefit in thyroid analog development.

Structured PICO

Does DITPA improve a composite endpoint of symptoms and morbidity/mortality in patients with NYHA class II to IV congestive heart failure?

P
Population
86 patients with New York Heart Association (NYHA) class II to IV congestive heart failure
I
Intervention
DITPA (3,5-diiodothyropropionic acid) treated for 6 months
C
Comparator
Placebo
O
Outcome
Composite congestive heart failure end point that classifies patients as improved, worsened, or unchanged based on symptom changes and morbidity/mortalitycomposite

Although the thyroid hormone analog DITPA improves hemodynamic and metabolic parameters in patients with heart failure, it is poorly tolerated and does not provide symptomatic benefit.

Limitations

  • Poor tolerability obscured the interpretation of congestive heart failure-specific effects

Cite This Study

Goldman et al. (2009) studied this question.

synapsesocial.com/papers/6a81100dd7cc3676436601a9https://doi.org/10.1161/circulationaha.108.834424

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Performance and Remodeling in Rabbits After Myocardial Infarction1995 · 95 citations
  2. 2Cardiovascular Effects of Intravenous Triiodothyronine in Patients Undergoing Coronary Artery Bypass Graft Surgery1996 · 140 citations
  3. 3A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure1991 · 2,849 citations
  4. 4The Clinical Significance of Subclinical Thyroid Dysfunction2007 · 1,423 citations
  5. 5Combination treatment with captopril and the thyroid hormone analogue 3,5-diiodothyropropionic acid. A new approach to improving left ventricular performance in heart failure.1993 · 62 citations