Why the study?
Does enalapril reduce mortality compared to hydralazine-isosorbide dinitrate in men with chronic congestive heart failure receiving digoxin and diuretics?
Population
804 men with chronic congestive heart failure receiving digoxin and diuretic therapy
Comparison
Enalapril 20 mg daily vs Hydralazine 300 mg plus isosorbide dinitrate 160…
Design
RCT, randomly assigned, double-blind
Follow-up
two years
Authors
Loading...
Supports preferring enalapril over hydralazine-isosorbide dinitrate to lower mortality in chronic HFrEF; confirms ACE inhibitor superiority versus vasodilators.
Does enalapril reduce mortality compared to hydralazine-isosorbide dinitrate in men with chronic congestive heart failure receiving digoxin and diuretics?
Enalapril provides a greater survival benefit than the combination of hydralazine and isosorbide dinitrate in men with chronic heart failure.
Cohn et al. (1991) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: