Why the study?
Autonomic Regulation Therapy using chronic VNS is in development for symptomatic heart failure, but requires effective titration methods beyond manual programming.
Does an automated titration algorithm safely increase stimulation intensity to target levels in a canine model of vagus nerve stimulation?
Does an automated titration algorithm safely increase stimulation intensity to target levels in a canine model of vagus nerve stimulation?
An automated titration algorithm for vagus nerve stimulation safely achieved target stimulation intensity in a canine model, suggesting a potential method to reduce the clinical burden of manual titration in heart failure patients.
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Automated titration reached target VNS intensity without adverse events in canines; leaves open translation to reduce titration burden in human HF.
Autonomic Regulation Therapy (ART) using chronic Vagus Nerve Stimulation (VNS) is in development for patients with heart failure who remain symptomatic despite standard care. In the ANTHEM-HF Pilot Study, a therapeutic VNS intensity was successfully achieved in patients with HFrEF using manually programmed VNS up-titration. An algorithm has been developed for automatically intensifying VNS in small increments to a programmable target intensity, and capable of adjustments during the up-titration process using a hand-held programmer or magnet.
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Libbus et al. (2020) studied this question.
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