Why the study?
Does ramipril reduce arterial blood pressure in spontaneously hypertensive rats?
Does ramipril reduce arterial blood pressure in spontaneously hypertensive rats?
Ramipril produces a dose-dependent, sustained 24-hour reduction in blood pressure in spontaneously hypertensive rats without disrupting circadian rhythms.
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Ramipril lowers BP dose-dependently in SHR; leaves open translation to human hypertension therapy.
Subchronic bolus administration of the angiotensin-converting-enzyme inhibitor ramipril caused a dose-dependent (0.1 to 10 mg.kg-1.d-1), yet each in his own way 24-hour sustained, reduction in arterial blood pressure in conscious unrestrained spontaneously hypertensive rats with telemetric recording, and 0.01 mg.kg-1.d-1 was a no-effect dose. This was accompanied by dose-dependent attenuation of heart rate lowering during periods of low locomotor activity. Neither effect persisted for more than a few days after cessation of the medication with full restoration of pretreatment levels. No dosage altered the circadian rhythm of blood pressure, heart rate and locomotor activity of the rats.
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Becker et al. (1997) studied this question.
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