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April 1, 1994Acta Physiologica Scandinavica

Density of L‐type calcium channels in ischaemically preconditioned porcine heart regions

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Why the study?

Does ischaemic preconditioning reduce the density or alter the state of L-type calcium channels in porcine hearts?

Population

8 porcine hearts

Comparison

Regional ischaemic preconditioning vs Control regions supplied by the circumflex…

Design

Preclinical

Authors

MSMathis K. StokkeOslo University HospitalGAGunnar AksnesOslo University HospitalKLKnut LandeOslo University Hospital

Discussion

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Implication

Ischaemic preconditioning does not alter L-type calcium channel density or affinity in porcine hearts; leaves open alternative protective mechanisms.

Structured PICO

Does ischaemic preconditioning reduce the density or alter the state of L-type calcium channels in porcine hearts?

P
Population
8 porcine hearts
I
Intervention
Regional ischaemic preconditioning (two 10-min occlusions of the mid left anterior descending artery, each followed by 30 min of reperfusion)
C
Comparator
Control regions supplied by the circumflex artery in the same hearts
O
Outcome
Density and dissociation constant of (+)-[3H]isradipine binding to L-type calcium channels (LCC)surrogate

Ischaemic preconditioning does not appear to involve local changes in the density or state of L-type calcium channels detectable by (+)-[3H]isradipine binding in a porcine model.

Cite This Study

Stokke et al. (1994) studied this question.

synapsesocial.com/papers/6a813edfd7cc367643661aaehttps://doi.org/10.1111/j.1748-1716.1994.tb09707.x

Topics

Women and heart disease
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Calcium Channel Blocking Agents on Infarct Size After Ischaemia-Reperfusion in Anaesthetised Pigs1991 · 17 citations
  2. 2Dihydropyridine Binding Sites in Aerobically Perfused, Ischemic, and Reperfused Rat Hearts1988 · 27 citations
  3. 3Myocardial potassium balance associated with regional ischaemia in the pig: effects of β‐adrenoceptor blockade, duration of ischaemia and preceding ischaemic periods1992 · 2 citations
  4. 4Clinical Trials: A Practical Approach.1984 · 2,951 citations