Neuroanatomic and Functional Correlates of Depressed Mood: The Cardiovascular Health Study
Population
3,371 US men and women aged 65 years or older who participated in the Cardiovascular Health Study between…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Requires prospective confirmation of lesion location effects; leaves open mediation by disability or cognition.
Structured PICO
P
Population
3,371 US men and women aged 65 years or older who participated in the Cardiovascular Health Study between 1992 and 1994
I
Intervention
MRI-identified infarcts in the basal ganglia and non-basal-ganglia areas
O
Outcome
Depressive symptomatology measured by Center for Epidemiologic Studies Depression Scale (CES-D) scorespatient reported
The association between cerebrovascular lesions and depressive symptoms in older adults appears to be mediated by the functional consequences of the lesions, such as physical disability and cognitive impairment.
Cite This Study
Sato et al. (1999) studied this question.