Key result
Small (<3 mm) basal ganglia lesions were significantly associated with reported depressive symptoms in a community-based cohort of 3660 elderly adults.
Why the study?
Are white and gray matter lesions associated with depressive symptoms in an elderly community-based population?
Population
3660 men and women participating in the Cardiovascular Health Study who underwent a standardized interview…
Design
Cohort
Authors
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Hypothesis-generating for cerebrovascular mechanisms in late-life depression; does not support practice change without further evidence.
Observational (n=3,660)
Are white and gray matter lesions associated with depressive symptoms in an elderly community-based population?
Small basal ganglia lesions on MRI are significantly associated with depressive symptoms in a large community-based elderly population, highlighting the role of cerebrovascular changes in geriatric depression.
Steffens et al. (1999) conducted an observational in Depressive symptoms and cerebrovascular disease (n=3,660). Small (<3 mm) basal ganglia lesions was evaluated on Reported depressive symptoms using a modified CES-D scale. Small (<3 mm) basal ganglia lesions were significantly associated with reported depressive symptoms in a community-based cohort of 3660 elderly adults.
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