Key result
Baseline cerebrovascular disease, including small basal ganglia and large cortical white-matter lesions, was associated with the occurrence, persistence, and worsening of depressive symptoms over 7 years.
Why the study?
Does cerebrovascular disease on neuroimaging predict the evolution of depressive symptoms in CHS participants?
Population
3236 Cardiovascular Health Study (CHS) participants who had an MRI brain scan
Comparison
Presence of vascular brain pathology on… vs Absence or lower severity of vascular brain…
Design
Cohort
Follow-up
up to 7 years
Authors
Loading...
May flag older adults for depression monitoring; hypothesis-generating and requires prospective trials before practice change.
Cohort (n=3,236)
Does cerebrovascular disease on neuroimaging predict the evolution of depressive symptoms in CHS participants?
Cerebrovascular disease identified on baseline MRI is associated with the occurrence, persistence, and worsening of depressive symptoms over time, supporting a link between vascular brain pathology and mood disorders.
Steffens et al. (2002) conducted a cohort in Cerebrovascular disease and depressive symptoms (n=3,236). Vascular brain pathology on neuroimaging was evaluated on Evolution of depressive symptoms (occurrence, persistence, and worsening). Baseline cerebrovascular disease, including small basal ganglia and large cortical white-matter lesions, was associated with the occurrence, persistence, and worsening of depressive symptoms over 7 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: