Why the study?
The physiological role of prolactin in the heart, particularly the diabetic heart, is largely unknown.
Does prolactin improve ventricular myocyte shortening and calcium transport in streptozotocin-induced diabetic rats?
Does prolactin improve ventricular myocyte shortening and calcium transport in streptozotocin-induced diabetic rats?
Prolactin exerts positive inotropic effects in ventricular myocytes from both normal and diabetic rats, partly through increased fractional release of sarcoplasmic reticulum calcium.
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Hypothesis-generating for prolactin's inotropic effects in diabetic myocytes; should not yet inform clinical practice.
Howarth et al. (2020) studied this question.
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