International Differences in Clinical Characteristics, Management, and Outcomes in Acute Heart Failure Patients: Better Short-Term Outcomes in Patients Enrolled in Eastern Europe and Russia in the PROTECT Trial
Why the study?
Does geographic region affect clinical characteristics, management, and outcomes in patients with acute heart failure and renal dysfunction?
Population
2033 patients with acute heart failure and renal dysfunction hospitalized at 173 sites in 17 countries
Comparison
Enrollment in different geographic regions vs Western Europe (used as reference region)
Design
Cohort
Follow-up
180 days
Authors
Discussion
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Member takes
Implication
Regional variations in acute HF outcomes warrant caution generalizing trial results; leaves open unmeasured confounders and care practices.
Structured PICO
Does geographic region affect clinical characteristics, management, and outcomes in patients with acute heart failure and renal dysfunction?
P
Population
2033 patients with acute heart failure and renal dysfunction hospitalized at 173 sites in 17 countries
I
Intervention
Enrollment in different geographic regions (Eastern Europe, Western Europe, Israel, North America, Russia, Argentina)
C
Comparator
Western Europe (used as reference region)
O
Outcome
60-day mortality or cardiovascular/renal hospitalizationcomposite
Significant regional variations exist in baseline characteristics, length of stay, and short-term rehospitalization rates among acute heart failure patients, independent of length of stay.
Limitations
- Requires external validation
Cite This Study
Mentz et al. (2014) studied this question.