Global Differences in Characteristics, Precipitants, and Initial Management of Patients Presenting With Acute Heart Failure
Key result
Global region of presentation significantly impacted acute heart failure management, including median time to first intravenous therapy (3.0 hours in North America vs <1.2 hours elsewhere; P<0.001).
Why the study?
Acute heart failure precipitates millions of hospital admissions globally, but previous registries have been country or region specific.
Population
18 553 adults hospitalized for acute heart failure across 358 sites in 44 countries
Design
Prospective international observational registry
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
Regional differences in acute HF care timing showed no in-hospital mortality impact; leaves open need for standardized protocols and longer-term outcome studies.
Study Design
Type
Observational (n=18,553)
Multicenter
Yes
Structured PICO
P
Population
18,553 adults (median age 67 years) hospitalized for acute heart failure across 44 countries, evaluated for regional differences in precipitants, treatments, and in-hospital outcomes.
O
Outcome
Heart failure etiologic factors and precipitants, treatments, and in-hospital outcomes among global regions
There are significant global regional differences in the precipitants, timing of intravenous therapy, and use of inotropes for patients presenting with acute heart failure.
Cite This Study
Filippatos et al. (2020) conducted an observational in Acute heart failure (n=18,553). Global region of presentation vs. Other global regions was evaluated on Heart failure etiologic factors and precipitants, treatments, and in-hospital outcomes among global regions. Global region of presentation significantly impacted acute heart failure management, including median time to first intravenous therapy (3.0 hours in North America vs <1.2 hours elsewhere; P<0.001).