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October 1, 1981AJP Renal Physiology

NaCl transport in mouse medullary thick ascending limbs. II. ADH enhancement of transcellular NaCl cotransport; origin of transepithelial voltage

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Population

Mouse medullary thick ascending limbs of Henle (mTALH)

Comparison

ADH (antidiuretic hormone) vs Absence of ADH

Design

Preclinical

Authors

SHS. C. HebertYale UniversityRCR. Michael CulpepperEast Carolina UniversityTAThomas E. AndreoliSuzuki (Japan)

Discussion

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Overview

Does not support clinical practice changes; leaves open translation of ADH effects on medullary thick ascending limb transport to humans.

Structured PICO

P
Population
Mouse medullary thick ascending limbs of Henle (mTALH)
I
Intervention
ADH (antidiuretic hormone)
C
Comparator
Absence of ADH
O
Outcome
Rate of net NaCl transport and rate of net Cl- absorptionsurrogate

ADH enhances transcellular NaCl cotransport in mouse medullary thick ascending limbs, increasing net salt absorption.

Limitations

  • Analytical data do not permit a distinction between wholly electroneutral apical membrane NaCl entry and a process with stoichiometry less than unity plus electrogenic Na+ transport.

Cite This Study

Hebert et al. (1981) studied this question.

synapsesocial.com/papers/6a815b8526f0d7dff79cd5c2https://doi.org/10.1152/ajprenal.1981.241.4.f432
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fluid dilution and efficiency of Na+transport in a mathematical model of a thick ascending limb cell2012 · 7 citations
  2. 2Transepithelial Ca<sup>2+</sup> and Mg<sup>2+</sup> Transport in the Cortical Thick Ascending Limb of Henle’s Loop of the Mouse Is a Voltage-Dependent Process1993 · 69 citations
  3. 3Evidence for conductive Cl- pathways across the cell membranes of the thin ascending limb of Henle's loop.1988 · 34 citations
  4. 4Cortical distal nephron Cl−transport in volume homeostasis and blood pressure regulation2013 · 53 citations
  5. 5Sodium reabsorption in thick ascending limb of Henle's loop: effect of potassium channel blockade in vivo2000 · 16 citations