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January 1, 1993Kidney & Blood Pressure Research

Transepithelial Ca2+ and Mg2+ Transport in the Cortical Thick Ascending Limb of Henle’s Loop of the Mouse Is a Voltage-Dependent Process

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Population

Isolated perfused cortical thick ascending limb (cTAL) of Henle’s loop of the mouse nephron

Comparison

Furosemide and diphenylamine-2-carboxylate, and… vs Baseline conditions without inhibitors or with…

Design

Preclinical

Authors

ASAntonio Di StefanoUniversity of Chieti-PescaraNRN. RoinelCollège de FranceCRC. de RouffignacCEA Paris-Saclay - Etablissement de Saclay

Discussion

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Overview

Does not inform human electrolyte management; extends passive reabsorption model in rodent TAL but leaves translation open.

Structured PICO

P
Population
Isolated perfused cortical thick ascending limb (cTAL) of Henle’s loop of the mouse nephron
I
Intervention
Furosemide (10^-4 mol/l, lumen) and diphenylamine-2-carboxylate (DPC, 10^-4 mol/l, bath), and manipulation of NaCl gradients
C
Comparator
Baseline conditions without inhibitors or with different NaCl gradients
O
Outcome
Transepithelial voltages (PDte) and transepithelial ion net fluxes (JNa, JCl, JK, JCa, JMg) measured by electron microprobe analysissurrogate

Transepithelial Ca2+ and Mg2+ reabsorption in the mouse cortical thick ascending limb is predominantly a passive process driven by the lumen-positive transepithelial voltage.

Cite This Study

Stefano et al. (1993) studied this question.

synapsesocial.com/papers/6a76a947d8eb58afc2bd51ffhttps://doi.org/10.1159/000173762
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NaCl transport in mouse medullary thick ascending limbs. II. ADH enhancement of transcellular NaCl cotransport; origin of transepithelial voltage1981 · 97 citations
  2. 2Microelectrode assessment of chloride-conductive properties of cortical collecting duct1984 · 88 citations
  3. 3Evidence for conductive Cl- pathways across the cell membranes of the thin ascending limb of Henle's loop.1988 · 34 citations
  4. 4Sodium reabsorption in thick ascending limb of Henle's loop: effect of potassium channel blockade in vivo2000 · 16 citations
  5. 5Mutual dependence of sodium and chloride absorption by renal distal tubule1984 · 72 citations